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Changing the way  medicine is administered

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SCIENCE OF THE DRUG DELIVERY WITHIN THE SKIN

Anatomically, the skin is made up of two major tissue layers, an outer epidermis and an underlying dermis, which together constitute the skin. The dermis itself contains two layers: the outermost layer is referred to as the papillary dermis while the deeper layer is known as the reticular dermis. The papillary dermis contains vast microcirculatory blood and lymphatic plexuses. Beneath the dermis is the subcutaneous tissue, which is composed of fatty and muscular tissue and an abundance of nerves.

What is skin?

SCIENCE OF THE DRUG DELIVERY WITHIN THE SKIN

THERE ARE THREE PRIMARY METHODS

BY WHICH DRUGS MAY BE INJECTED:

 

1. Intramuscular   2. Subcutaneous   3. Intradermal

 

The intradermal injection method typically requires a standard needle to be carefully inserted into the dermis at an angle (15 degrees), making it a precise and awkward procedure for the user. This explains why insulin and many other drugs are not administered intradermally. This has been the major challenge for patients or care-providers administering an intradermal injection and is why a syringe is mainly administerd into the subcutaneous or intramuscular tissue.

Pain-Free Micro-Needle Drug Delivery Technology Targets The Dermis Layers

Get the Facts...

700,000 needlestick injuries each year in the US alone.

 

For every 100 hospital beds, 30 will sustain a needlestick injury.

 

The national economic burden of needlestick injuries is estimated to be $65 million.

 

Needlestick injuries may expose workers to bloodborne pathogens such as human immunodeficiency virus (HIV), hepatitis B virus, or hepatitis C virus.

 

Targetting the skin means that drug delivery can take place anywhere on the body, rather than the five often overused subcutaneous sites for injection. The pressure required to administer or self-administer the drug via the microneedle is minimal, and drug doses are premeasured and identified. This makes the Micro-Needle easy to use.

NO MESS - NO OVER OR UNDER DOSING - NO PAIN

Intradermal Drug Delivery Improves Efficacy. Our intradermal drug delivery design actually changes the pharmacokinetic profile, enhances the uptake and bio-availability of the protein, and improves efficacy of these compounds as compared to standard efficacy of intramuscular or subcutaneous administration.

 

The needle retracts and locks to prevent needle stick injuries.

SAFE, SIMPLE & PAIN FREE

THE PKA MICRO-NEEDLE REPLACES THE SYRINGE WITH A PAINLESS INTERDERMAL DELIVERY SYSTEM

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Lakefield, ON

(705) 652-6100

info@pkasofttouch.com